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Hormones

Estrone (E1) Blood Test

Estrone (E1) is a weaker form of estrogen that becomes the dominant estrogen after menopause. It is produced mainly in fat tissue and the adrenal glands. Abnormal levels may indicate hormonal changes worth discussing with your healthcare provider.

Turnaround up to 72 hours, estimate Turnaround: up to 72 hours after your blood draw (estimate).

Reference Ranges

No established reference range

No reliable reference interval can be established for estrone: the Dutch laboratories that offer the test publish male values that differ by a factor of 1.7, and the published values apply only to LC-MS/MS. Estrone is rarely ordered as a stand-alone test; we would rather show no value than one that is wrong.

Unit: pmol/l

Reference values can vary between laboratories. Discuss your results with your GP for explanation and treatment decisions.

Estrone (E1): what this test measures

This test measures the level of estrone (E1) in your blood. Estrone is produced by fat tissue, the adrenal glands, and the ovaries. After menopause it becomes the primary circulating estrogen. Your healthcare provider may use this result to assess your overall hormonal status.

Estrone (E1): why this value matters

Estrone plays a significant role in postmenopausal health and may influence bone density, body composition, and metabolic function. Elevated levels could suggest increased estrogen production from fat tissue. Discussing your results with a healthcare provider may help guide appropriate health decisions.

Estrone (E1): how the blood test works

Referral
No GP referral needed. After the order we arrange the referral through ZorgDomein, within one business day; orders after 17:00 or at the weekend start on the next business day. ZorgDomein emails a barcode, and that barcode is what the draw site needs.
The draw
A blood draw from a vein in the arm, at a partner laboratory's draw site. No home kit, no finger prick.
Results
Turnaround: up to 72 hours after your blood draw (estimate).
Where
650+ draw sites run by independent laboratories across the Netherlands. Draw sites

Estrone (E1): when is testing worthwhile?

Your healthcare provider may recommend estrone testing during menopause evaluation, when investigating unexplained weight changes, or as part of a comprehensive hormone panel. Testing could also be suggested for monitoring hormone replacement therapy effectiveness. Consult your provider for personalised guidance.

Estrone (E1): symptoms of a high or low value

Low Levels

Some people may experience accelerated bone loss, increased fatigue, or changes in body composition when estrone levels are low. Joint discomfort and skin changes could also suggest reduced estrogen activity. A healthcare provider can help evaluate whether your levels require attention.

High Levels

Elevated estrone levels may be associated with weight gain, bloating, breast tenderness, or irregular bleeding. High levels could suggest increased conversion from fat tissue or other hormonal imbalances. Your healthcare provider can help determine whether further investigation is appropriate.

Estrone (E1): what to do about an abnormal value

Male

If Low

Low estrone is generally not concerning in men.

If High

Elevated estrone may indicate increased aromatase activity. Consider weight management.

Female

If Low

Low estrone may indicate menopause or ovarian dysfunction.

If High

Elevated estrone may indicate excess body weight or hormone therapy. Discuss with your healthcare provider.

Estrone (E1): lifestyle and this value

Maintaining a healthy body weight may help regulate estrone levels, as fat tissue is a primary production site. Regular exercise, a balanced diet, and limiting alcohol consumption could support healthy estrogen balance. Always consult your healthcare provider before making significant changes.

Estrone (E1): frequently asked questions

What is estrone?

Estrone is a weaker estrogen that becomes dominant after menopause, mainly produced in fat tissue.

Why test estrone specifically?

Estrone testing may help evaluate postmenopausal hormonal status and overall estrogen activity.

Does body weight affect estrone?

Yes, fat tissue produces estrone, so body composition may influence your levels significantly.

Tests with related values

These panels measure values from the same category as this marker.

Results without a doctor's assessment

You receive your values with the unit and reference range. A doctor's assessment is not part of this site. Discuss your results with your GP for explanation and treatment decisions.

Estrone (E1)

€39,-