Endomysial IgA: Normal Values and What a Positive Result Means
Endomysium IgA is a highly specific antibody test for coeliac disease. The endomysium is a connective tissue layer surrounding muscle fibres, and in coeliac disease the immune system produces IgA antibodies against this tissue when exposed to gluten. A positive result is strongly suggestive of coeliac disease, though confirmation by a healthcare provider is always required.
Turnaround up to 72 hours, estimate Turnaround: up to 72 hours after your blood draw (estimate).
Endomysium IgA: what this test measures
This test detects IgA antibodies directed against endomysial tissue. It is one of the most specific tests for coeliac disease, with a specificity approaching 100% in experienced laboratories. It is often used to confirm positive anti-TTG results.
Endomysium IgA: why this value matters
Due to its very high specificity, a positive endomysium IgA result strongly supports a diagnosis of coeliac disease. This helps healthcare providers decide on further management including potential biopsy and dietary intervention.
Endomysium IgA: how the blood test works
- Referral
- No GP referral needed. After the order we arrange the referral through ZorgDomein, within one business day; orders after 17:00 or at the weekend start on the next business day. ZorgDomein emails a barcode, and that barcode is what the draw site needs.
- The draw
- A blood draw from a vein in the arm, at a partner laboratory's draw site. No home kit, no finger prick.
- Results
- Turnaround: up to 72 hours after your blood draw (estimate).
- Where
- 650+ draw sites run by independent laboratories across the Netherlands. Draw sites
Endomysium IgA: how to prepare
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Preferably keep eating gluten
RecommendedThis test is only reliable if you ate gluten normally for the 6 weeks before.
- Water is always fine. Drink as usual beforehand, it makes the draw easier.
- Take your usual medication, unless your own doctor told you otherwise.
Endomysium IgA: when is testing worthwhile?
Endomysium IgA is typically ordered alongside or after anti-TTG testing to confirm coeliac disease. You must be consuming gluten regularly at the time of testing. Consult your healthcare provider for guidance on when this test is appropriate.
Endomysium IgA: symptoms of a high or low value
Low Levels
A negative endomysium IgA result is reassuring and suggests coeliac disease is unlikely, provided you were consuming gluten and do not have IgA deficiency. Some individuals with mild coeliac disease may still test negative.
High Levels
A positive endomysium IgA is strongly associated with coeliac disease. Common symptoms include chronic diarrhoea, bloating, fatigue, weight loss, anaemia, and in children, growth problems. Your healthcare provider will guide the next diagnostic steps.
Endomysium IgA: lifestyle and this value
If coeliac disease is confirmed, a strict gluten-free diet is essential. Gluten is found in wheat, barley, and rye. Reading food labels carefully and working with a dietitian ensures nutritional adequacy while avoiding gluten.
Endomysium IgA: frequently asked questions
How is the endomysium IgA test different from anti-TTG?
Both target related aspects of the coeliac immune response. Anti-TTG is more sensitive and used for initial screening, while endomysium IgA is more specific and often used for confirmation.
Can this test be falsely negative?
Yes — if you have IgA deficiency or are on a gluten-free diet, the test may produce a false-negative result.
Do I need a biopsy if endomysium IgA is positive?
In many adult cases, a biopsy is recommended to confirm the diagnosis. However, guidelines are evolving, and some cases with very high antibody titres may allow a no-biopsy diagnosis. Discuss this with your healthcare provider.
Results without a doctor's assessment
You receive your values with the unit and reference range. A doctor's assessment is not part of this site. Discuss your results with your GP for explanation and treatment decisions.
Endomysium IgA
€63,-