Beta-2 Glycoprotein Screening
Beta-2 Glycoprotein Screening detects antibodies against beta-2 glycoprotein I (B2GPI), a plasma protein that binds phospholipids. Anti-B2GPI antibodies are one of the three criteria antibodies for antiphospholipid syndrome (APS) and may be the sole positive antibody in some APS patients.
Turnaround up to 72 hours, estimate Turnaround: up to 72 hours after your blood draw (estimate).
Beta-2 Glycoprotein Screening: what this test measures
This test measures IgG and/or IgM antibodies against beta-2 glycoprotein I. B2GPI is considered the primary antigenic target in antiphospholipid syndrome.
Beta-2 Glycoprotein Screening: why this value matters
Anti-B2GPI antibodies may be the only positive marker in some APS patients. IgG anti-B2GPI is most strongly associated with thrombotic risk. Testing completes the antiphospholipid antibody profile.
Beta-2 Glycoprotein Screening: how the blood test works
- Referral
- No GP referral needed. After the order we arrange the referral through ZorgDomein, within one business day; orders after 17:00 or at the weekend start on the next business day. ZorgDomein emails a barcode, and that barcode is what the draw site needs.
- The draw
- A blood draw from a vein in the arm, at a partner laboratory's draw site. No home kit, no finger prick.
- Results
- Turnaround: up to 72 hours after your blood draw (estimate).
- Where
- 650+ draw sites run by independent laboratories across the Netherlands. Draw sites
Beta-2 Glycoprotein Screening: when is testing worthwhile?
Testing could be indicated alongside anti-cardiolipin and lupus anticoagulant as part of complete APS evaluation, or when those tests are negative but clinical suspicion for APS remains.
Beta-2 Glycoprotein Screening: symptoms of a high or low value
Low Levels
A negative result is normal and does not require follow-up in the absence of clinical suspicion.
High Levels
Positive anti-B2GPI contributes to APS diagnosis when persistent and combined with clinical criteria (thrombosis or pregnancy morbidity).
Beta-2 Glycoprotein Screening: lifestyle and this value
If APS is confirmed through persistent antibody positivity, follow specialist guidance on anticoagulation. Reduce modifiable thrombosis risk factors and avoid oestrogen-containing medications.
Beta-2 Glycoprotein Screening: frequently asked questions
Why test for B2GPI in addition to cardiolipin?
Some APS patients are positive only for anti-B2GPI. Testing all three criteria antibodies ensures comprehensive screening and prevents missed diagnoses.
Is B2GPI the actual target in APS?
Research suggests B2GPI is the primary antigenic target. Anti-cardiolipin antibodies are actually directed against B2GPI bound to cardiolipin rather than cardiolipin alone.
Can B2GPI antibodies disappear over time?
Rarely. Persistent positivity is characteristic of APS. Transient positivity can occur with infections and is excluded by the 12-week confirmation requirement.
Results without a doctor's assessment
You receive your values with the unit and reference range. A doctor's assessment is not part of this site. Discuss your results with your GP for explanation and treatment decisions.
Beta-2 Glycoprotein Screening
€65,-